A dispensing system includes a frame, a dispensing unit gantry movably coupled to the frame, and a dispensing unit coupled to the dispensing unit gantry. The dispensing unit further includes a vision system gantry coupled to the frame and a vision system coupled to the vision system gantry. A controller is coupled to the dispensing unit gantry, the dispensing unit, the vision system gantry, and the vision system. The controller is configured to obtain an image of a fiducial provided on the electronic substrate, obtain an image of at least a portion of an object positioned on the electronic substrate, orient the object with respect to the dispensing unit, and perform a dispense operation to secure the object to the electronic substrate. Methods of dispensing material on a substrate are further disclosed.