发明申请
- 专利标题： Methylation Biomarkers for Diagnosis of Prostate Cancer
- 专利标题（中）： 用于诊断前列腺癌的甲基化生物标志物
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申请号： US14008480申请日： 2012-04-02
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公开(公告)号： US20140094380A1公开(公告)日： 2014-04-03
- 发明人: Gavin J. Sherlock , James Duane Brooks , Richard M. Myers , Yuya Kobayashi , Devin M. Absher
- 申请人： Gavin J. Sherlock , James Duane Brooks , Richard M. Myers , Yuya Kobayashi , Devin M. Absher
- 申请人地址： US CA Palo Alto
- 专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人地址： US CA Palo Alto
- 国际申请： PCT/US2012/031876 WO 20120402
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Biomarkers for diagnosis and prognosis of prostate cancer are provided. The biomarkers are promoter sequences have altered methylation patterns relative to normal prostate tissue. Altered expression of DNA methyltransferases (DNMT) and proteins that interact with DNMT result in increased methylation at a subset of prostate tumor hypermethylation sites.
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