Invention Application
- Patent Title: INTERLEUKIN-13 BINDING PROTEINS
- Patent Title (中): INTERLEUKIN-13结合蛋白
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Application No.: US14101145Application Date: 2013-12-09
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Publication No.: US20140099313A1Publication Date: 2014-04-10
- Inventor: Chengbin WU , Richard W. DIXON , Jonathan P. BELK , Maria A. ARGIRIADI , Hua YING , Carolyn A. CUFF , Terry L. MELIM , Shankar KUMAR , Paul R. HINTON , Yan CHEN
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: ABBVIE INC.
- Current Assignee: ABBVIE INC.
- Current Assignee Address: US IL North Chicago
- Main IPC: C07K16/24
- IPC: C07K16/24 ; A61K45/06 ; A61K39/395

Abstract:
The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
Public/Granted literature
- US09592293B2 Interleukin-13 binding proteins Public/Granted day:2017-03-14
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