发明申请
- 专利标题: PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS MEGATERIUM
- 专利标题(中): 生产西红柿或黑麦草中的羟丙酸的方法
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申请号: US13821953申请日: 2011-09-09
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公开(公告)号: US20140099673A1公开(公告)日: 2014-04-10
- 发明人: Vincenza Corsa , Alessandro Negro , Sonia Bisicchia
- 申请人: Vincenza Corsa , Alessandro Negro , Sonia Bisicchia
- 申请人地址: IT Abano Terme (PD)
- 专利权人: FIDIA FARMACEUTICI S.P.A.
- 当前专利权人: FIDIA FARMACEUTICI S.P.A.
- 当前专利权人地址: IT Abano Terme (PD)
- 优先权: ITMI2010A001641 20100909
- 国际申请: PCT/EP11/65641 WO 20110909
- 主分类号: C12P19/26
- IPC分类号: C12P19/26
摘要:
The present invention relates to a method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid.
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