A system and method for providing an eNodeB with the flexibility to configure a Channel State Information (CSI) report to match a specific Coordinated Multipoint (CoMP) transmission hypothesis, which is a candidate for a downlink transmission to a User Equipment (UE) is disclosed. A UE receives, from the eNodeB, a configuration message that specifies a CSI report. The CSI report is specified by a particular interference hypothesis and a particular desired signal hypothesis corresponding to data transmission over at least one effective channel characterized by a specific reference signal. The UE estimates interference according to the interference hypothesis, and/or estimates at least one effective channel by performing measurements on the specific reference signal, and determines a CSI report based on the interference estimation and on the estimated effective channel. The UE also transmits the CSI report to the eNodeB.