A method and apparatus for transmitting and receiving a signal using a channel output feedback in a wireless communication system and Hybrid-Automatic Repeat Request (ARQ) are provided. The method and apparatus include a transmitter configured to transmit to a base station and a first packet on a precoder received from the base station. A receiver configured to receive, from the base station, a Channel Output Feedback (COF) of the transmitted first packet and information for transmitting a second packet. A controller configured to prepare a variant of the second packet using the COF and the received information for transmitting the second packet, and to control to transmit the prepared variant to the base station.