发明申请
US20140113880A1 MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS
审中-公开
用于治疗感冒的改良的2'和3'-核苷酸产物
- 专利标题： MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS
- 专利标题（中）： 用于治疗感冒的改良的2'和3'-核苷酸产物
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申请号： US14146520申请日： 2014-01-02
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公开(公告)号： US20140113880A1公开(公告)日： 2014-04-24
- 发明人: Richard Storer , Gilles Gosselin , Jean-Pierre Sommadossi , Paolo LaColla
- 申请人： Idenix Pharmaceuticals, Inc. , L'Universite Montpellier II , Centre National de la Recherche Scientiflque , Universita degli Studi di Cagliari
- 申请人地址： US MA Cambridge FR Montpellier FR Paris IT Cagliari
- 专利权人： Idenix Pharmaceuticals, Inc.,L'Universite Montpellier II,Centre National de la Recherche Scientiflque,Universita degli Studi di Cagliari
- 当前专利权人： Idenix Pharmaceuticals, Inc.,L'Universite Montpellier II,Centre National de la Recherche Scientiflque,Universita degli Studi di Cagliari
- 当前专利权人地址： US MA Cambridge FR Montpellier FR Paris IT Cagliari
- 主分类号： C07H19/16
- IPC分类号： C07H19/16
摘要：
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
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