发明申请
- 专利标题： METHOD FOR PREPARATION OF A HIGH CONCENTRATION LIQUID FORMULATION OF AN ANTIBODY
- 专利标题（中）： 制备高浓度液体制剂抗体的方法
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申请号： US14068074申请日： 2013-10-31
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公开(公告)号： US20140120086A1公开(公告)日： 2014-05-01
- 发明人: Markus RAST , Peter SKUFCA , Wolfram STEINHILBER , Gerhard BECKER , Jurgen VOLZ , Wolfgang ISE
- 申请人： Takeda GmbH
- 申请人地址： DE Konstanz
- 专利权人： Takeda GmbH
- 当前专利权人： Takeda GmbH
- 当前专利权人地址： DE Konstanz
- 优先权： EP12190855.2 20121031
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.
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