The present invention provides a method and a device for inter-cell interference coordination. The method comprises: acquiring sub-frame configuration information of neighbor cells; determining whether the neighbor cells are configured with transmissions in different directions on the same sub-frame; and if yes, performing interference coordination between the neighbor cells according to acquired data transmission-related information of the neighbor cells on the same sub-frame. Through the present invention, neighbor TDD base station cells are enabled to perform transmissions in different directions on the same time resource, interference is avoided through the interference coordination, and the situation in the conventional TDD interference coordination method that different cells are forced to use the same sub-frame configuration and cannot adapt to service requirements of the cells is avoided.