A roller pump including a drive shaft, a motor, a roller head assembly, a stator housing, and an occlusion adjustment assembly. The drive shaft is coupled to the motor. The roller head assembly includes a hub, a slide body, and a roller. The hub is mounted to the drive shaft, and maintains the slide body and the roller. The stator housing forms a raceway receiving surface. The occlusion adjustment assembly includes an actuator knob, an actuating structure, and a ground shaft. The actuating structure interfaces with the slide body, and thus the roller, with rotation of the knob. The ground shaft supports the knob and is rotationally isolated from the drive shaft. A user and optionally a control system can adjust occlusion while the pump continuously delivers a fluid medium.