发明申请
US20140127260A1 HPV VACCINE FORMULATIONS COMPRISING ALUMINUM ADJUVANT AND METHODS OF PRODUCING SAME
审中-公开
包含铝调制剂的HPV疫苗制剂及其生产方法
- 专利标题： HPV VACCINE FORMULATIONS COMPRISING ALUMINUM ADJUVANT AND METHODS OF PRODUCING SAME
- 专利标题（中）： 包含铝调制剂的HPV疫苗制剂及其生产方法
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申请号： US14126992申请日： 2012-06-22
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公开(公告)号： US20140127260A1公开(公告)日： 2014-05-08
- 发明人: Ramesh V. Chintala , Akhilesh Bhambhani
- 申请人： Ramesh V. Chintala , Akhilesh Bhambhani
- 国际申请： PCT/US2012/043694 WO 20120622
- 主分类号： A61K39/12
- IPC分类号： A61K39/12
摘要：
The invention provides human papillomavirus (HPV) antigen formulations which show increased antigen stability. More specifically, the invention provides stable HPV formulations comprising HPV virus-like particles (VLPs) bound to an aluminum salt adjuvant and further comprise a combination of sucrose and mannitol. The vaccine formulations of the invention are stable following freeze-thaw and freeze-drying. Also provided are lyophilized and frozen HPV vaccine formulations comprising HPV VLPs of at least one HPV type adsorbed onto an aluminum salt adjuvant, sucrose, and mannitol. Methods of making the stable vaccine formulations of the invention are also provided.
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