发明申请
US20140128382A1 5-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO- AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
有权
5代替IMINOTHIAZINES及其单和二氧化物作为BACE抑制剂，组合物及其使用
- 专利标题： 5-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO- AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
- 专利标题（中）： 5代替IMINOTHIAZINES及其单和二氧化物作为BACE抑制剂，组合物及其使用
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申请号： US14110363申请日： 2012-04-12
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公开(公告)号： US20140128382A1公开(公告)日： 2014-05-08
- 发明人: Wen-Lian Wu , Duane A. Burnett , Andrew W. Stamford , Jared N. Cumming , Chad E. Bennett , Eric J. Gilbert , Jack D. Scott , Younong Yu , Xuanjia Peng
- 申请人： Wen-Lian Wu , Duane A. Burnett , Andrew W. Stamford , Jared N. Cumming , Chad E. Bennett , Eric J. Gilbert , Jack D. Scott , Younong Yu , Xuanjia Peng
- 优先权： CNPCT/CN2012/000435 20120405
- 国际申请： PCT/CN2012/000497 WO 20120412
- 主分类号： C07D279/12
- IPC分类号： C07D279/12 ; A61K45/06 ; C07D417/04 ; A61K31/541 ; C07D498/04 ; C07D417/12 ; C07D471/04 ; C07D487/04 ; C07D513/04 ; A61K31/54 ; C07D417/14
摘要：
The present invention discloses certain iminothiazine compounds and mono- and dioxides thereof, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein each of variables shown in the formula are as defined herein. The compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and uses, including Alzheimer's disease, are also disclosed.
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