发明申请
- 专利标题： Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure
- 专利标题（中）： 具有改变闭环动力学的二取代马来酸酐
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申请号： US14119074申请日： 2012-05-31
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公开(公告)号： US20140128584A1公开(公告)日： 2014-05-08
- 发明人: Andrei V. Blokhin , David B. Rozema , Jonathan D. Benson , Jeffrey C. Carlson
- 申请人： Andrei V. Blokhin , David B. Rozema , Jonathan D. Benson , Jeffrey C. Carlson
- 申请人地址： US WI Madison
- 专利权人： ARROWHEAD MADISON INC.
- 当前专利权人： ARROWHEAD MADISON INC.
- 当前专利权人地址： US WI Madison
- 国际申请： PCT/US12/40130 WO 20120531
- 主分类号： C07D307/89
- IPC分类号： C07D307/89 ; C07D307/60 ; C07H15/26
摘要：
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
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