发明申请
US20140134172A1 ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF
有权
ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途
- 专利标题： ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF
- 专利标题（中）： ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途
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申请号： US14068976申请日： 2013-10-31
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公开(公告)号： US20140134172A1公开(公告)日： 2014-05-15
- 发明人: Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
- 申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
- 申请人地址： US IL North Chicago
- 专利权人： ABBVIE INC.
- 当前专利权人： ABBVIE INC.
- 当前专利权人地址： US IL North Chicago
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K45/06 ; C07K16/22 ; A61K39/395
摘要：
Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
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