发明申请
- 专利标题： ANTIBODY CONJUGATES
- 专利标题（中）： 抗体结合
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申请号： US14146389申请日： 2014-01-02
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公开(公告)号： US20140147906A1公开(公告)日： 2014-05-29
- 发明人: Christopher Bieniarz , Jennifer Wong , Mark Lefever , Jerome W. Kosmeder, II , Julia Ashworth-Sharpe , Casey A. Kernag
- 申请人： Ventana Medical Systems, Inc.
- 申请人地址： US AZ Tucson
- 专利权人： Ventana Medical Systems, Inc.
- 当前专利权人： Ventana Medical Systems, Inc.
- 当前专利权人地址： US AZ Tucson
- 主分类号： C12N9/16
- IPC分类号： C12N9/16 ; C12N9/08 ; C07K16/42 ; C07K16/44
摘要：
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
公开/授权文献
- US09315789B2 Antibody conjugates 公开/授权日：2016-04-19
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