One embodiment of the present invention provides a system for performing DC offset cancellation for a wireless receiver that includes one or more amplification stages between a demodulator and a baseband digital signal processor (DSP). During operation, the system calibrates values of static DC offset associated with a plurality of gain settings for at least one amplification stage, stores the calibrated DC offset values in a lookup table, receives a current gain setting for the amplification stage, maps a DC offset value from the lookup table based on the current gain setting, and cancels static DC offset for the amplification stage using the mapped DC offset value.