发明申请
- 专利标题： SMALL MOLECULE THERAPEUTIC COMPOUNDS TARGETING THIOESTERASE DEFICIENCY DISORDERS AND METHODS OF USING THE SAME
- 专利标题（中）： 小分子治疗化学物质治疗精神病药物缺陷性疾病及其使用方法
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申请号： US14110393申请日： 2012-04-09
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公开(公告)号： US20140148513A1公开(公告)日： 2014-05-29
- 发明人: Anil Baran Mukherjee , Chinmoy Sarkar , Zhongjian Zhang
- 申请人： Anil Baran Mukherjee , Chinmoy Sarkar , Zhongjian Zhang
- 申请人地址： US MD Bethesda
- 专利权人： DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY,
- 当前专利权人： DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY,
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US12/32772 WO 20120409
- 主分类号： A61K31/133
- IPC分类号： A61K31/133 ; A61K45/06
摘要：
The invention provides methods of inhibiting the development or progression of a thioesterase deficiency disorder in a mammal by the administration of a compound that functionally mimics the enzymatic activity of all thioesterases in mammals. Such thioesterase deficiency disorders include cancers and adult- or infant-neuronal ceroid lipofuscinoses (NCLs). The invention also provides small molecule mimics of thioesterases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds and methods of using the same.
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