A method and system for managing a virtual computing system including an event source configured to send an event to a destination virtual machine (VM) executing a memory monitoring instruction on a designated address range of a host memory. A hypervisor instructs a destination virtual central processing unit (VCPU) associated with the destination VM to execute the memory monitoring instruction to the designated address range of a memory. A physical CPU associated with the designated address range is configured not to perform an exit to the hypervisor in response to execution of the memory monitoring instruction by the destination VCPU. The hypervisor instructs an event source to write data to the designated address range to send an event for performance by the destination VM, wherein the destination VM wakes up and performs the identified event in response to the event source writing to the identified address range.