发明申请
- 专利标题： Salinosporamides and Methods of Use Thereof
- 专利标题（中）： Salinosporamides及其使用方法
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申请号： US14139692申请日： 2013-12-23
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公开(公告)号： US20140178354A1公开(公告)日： 2014-06-26
- 发明人: William Fenical , Paul Jensen , Tracy Mincer , Robert H.R. Feling
- 申请人： The Regents of the University of California
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 主分类号： A61K31/407
- IPC分类号： A61K31/407 ; A61K45/06 ; C07D491/044
摘要：
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
公开/授权文献
- US09078881B2 Salinosporamides and methods of use thereof 公开/授权日：2015-07-14
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