发明申请
- 专利标题： Heterocyclyl Pyrimidine Analogues As JAK Inhibitors
- 专利标题（中）： 杂环嘧啶类似物作为JAK抑制剂
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申请号： US14234662申请日： 2012-07-24
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公开(公告)号： US20140179664A1公开(公告)日： 2014-06-26
- 发明人: Jay Freeman , Valerie Reader , Glynn Addison , Nigel Ramsden , Jane Elizabeth Scanlon , Richard John Harrison
- 申请人： Jay Freeman , Valerie Reader , Glynn Addison , Nigel Ramsden , Jane Elizabeth Scanlon , Richard John Harrison
- 申请人地址： GB Brentford, Middlesex
- 专利权人： Cellzome Limited
- 当前专利权人： Cellzome Limited
- 当前专利权人地址： GB Brentford, Middlesex
- 优先权： EP11175807.4 20110728
- 国际申请： PCT/EP2012/064515 WO 20120724
- 主分类号： C07D491/107
- IPC分类号： C07D491/107 ; C07D403/14 ; C07D413/14 ; C07D403/12
摘要：
The present invention relates to compounds of formula (I) wherein X1 to X5, Z1 to Z3, Y0, RY1, RY2 and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
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