A display device and a method of driving a display device including: storing information on a stitch pattern; setting a data processing region disposed in a vicinity of a horizontal center line of a display panel and including a plurality of pixels; and performing data processing of changing gray of data for a portion of the plurality of pixels of the data processing region according to the information on the stitch pattern. The display panel includes a plurality of pixels arranged in a form of a matrix, a plurality of first data lines disposed in a first display panel region on a first side of the horizontal center line, and a plurality of second data lines disposed in a second display panel region on a second side of the horizontal center line opposite the first side.