发明申请
- 专利标题： Azole Compounds as PIM Inhibitors
- 专利标题（中）： 唑类化合物作为PIM抑制剂
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申请号： US14006285申请日： 2012-03-21
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公开(公告)号： US20140187553A1公开(公告)日： 2014-07-03
- 发明人: Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L.M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
- 申请人： Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L.M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
- 申请人地址： US CA Thousands Oaks
- 专利权人： AMGEM INC.
- 当前专利权人： AMGEM INC.
- 当前专利权人地址： US CA Thousands Oaks
- 国际申请： PCT/US12/29997 WO 20120321
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D487/04 ; C07D417/04 ; C07D471/04 ; C07D417/14
摘要：
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
公开/授权文献
- US09321756B2 Azole compounds as PIM inhibitors 公开/授权日：2016-04-26
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