Invention Application
US20140206876A1 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists
有权
2-（取代的乙炔基）喹啉衍生物作为mGLUr5拮抗剂
- Patent Title: 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists
- Patent Title (中): 2-（取代的乙炔基）喹啉衍生物作为mGLUr5拮抗剂
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Application No.: US13943019Application Date: 2013-07-16
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Publication No.: US20140206876A1Publication Date: 2014-07-24
- Inventor: Sun Joon MIN , Yong Seo CHO , Ae Nim PAE , Eun Jeong LIM , Ji Yeong KIM , Myung Hee SON , Jae Kyun LEE
- Applicant: Korea Institute of Science and Technology
- Priority: KR10-2013-0007540 20130123
- Main IPC: C07D215/06
- IPC: C07D215/06 ; C07D215/20 ; C07D401/06
Abstract:
Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).
Public/Granted literature
- US08946431B2 2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists Public/Granted day:2015-02-03
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