The present document provides a method and wireless device for implementing route transmission based on a single IPv6 address prefix. The method includes: when a wireless device succeeds in IPv6-based dialing and obtains one 64-bit-long IPv6 address prefix from a network side, the wireless device first setting apart a 126-bit IPv6 address prefix from the prefix, and then allocating the 126-bit IPv6 address prefix to a WAN interface, allocating the 64-bit-long IPv6 address prefix to a LAN interface, and notifying a user terminal connected to the LAN interface of the IPv6 prefix of the LAN interface, so that the user terminal connected to the LAN interface generates its own IPv6 address through a stateless address auto-configuration mechanism for communication. With the technical solutions of the present document, in an IPv4/IPv6 dual stack mode, IPv4 and IPv6 protocol stacks operate normally, and the radio resource consumption is reduced.