发明申请
- 专利标题： MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
- 专利标题（中）： 能与配偶结合的单甲基化合物
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申请号： US14194106申请日： 2014-02-28
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公开(公告)号： US20140220047A1公开(公告)日： 2014-08-07
- 发明人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Toni Beth Kline
- 申请人： Seattle Genetics, Inc.
- 申请人地址： US WA Bothell
- 专利权人： Seattle Genetics, Inc.
- 当前专利权人： Seattle Genetics, Inc.
- 当前专利权人地址： US WA Bothell
- 主分类号： A61K47/48
- IPC分类号： A61K47/48
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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