发明申请
![5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES](/docs/US/2014-08-14/US20140228349A1/abs.jpg.600x600.jpg)
- 专利标题： 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES
- 专利标题（中）： 5,7-取代的咪唑并[1,2-C]吡啶
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申请号： US14351415申请日： 2012-10-09
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公开(公告)号： US20140228349A1公开(公告)日： 2014-08-14
- 发明人: Mark Laurence Boys , Laurence E. Burgess , C. Todd Eary , Robert Groneberg , Bruno P. Hache , Darren Harvey , Erik James Hicken , Christopher F. Kraser , Ellen Laird , David A. Moreno , Mark C. Munson , Li Ren , John E. Robinson , Stephen T. Schlachter
- 申请人： Array BioPharma Inc.
- 国际申请： PCT/US12/59282 WO 20121009
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
![5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES](/abs-image/US/2014/08/14/US20140228349A1/abs.jpg.150x150.jpg)
摘要：
Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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