发明申请
US20140235593A1 SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES
有权
取代的2-烷基-1-氧代-N-苯基-3-异喹啉-1,2,3,4-四氢喹啉-4-羧酸酰胺用于抗菌治疗
- 专利标题： SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES
- 专利标题（中）： 取代的2-烷基-1-氧代-N-苯基-3-异喹啉-1,2,3,4-四氢喹啉-4-羧酸酰胺用于抗菌治疗
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申请号： US14240994申请日： 2012-08-24
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公开(公告)号： US20140235593A1公开(公告)日： 2014-08-21
- 发明人: Rodney Kiplin Guy , Fangyi Zhu , Wendyam Armand Guiguemde , David Floyd , Spencer Knapp , Philip Stein , Steve Castro
- 申请人： Rodney Kiplin Guy , Fangyi Zhu , Wendyam Armand Guiguemde , David Floyd , Spencer Knapp , Philip Stein , Steve Castro
- 申请人地址： US TN MEMPHIS US NJ NEW BRUNSWICK CH GENEVA
- 专利权人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL,RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY,MMV MEDICINES FOR MALARIA VENTURE
- 当前专利权人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL,RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY,MMV MEDICINES FOR MALARIA VENTURE
- 当前专利权人地址： US TN MEMPHIS US NJ NEW BRUNSWICK CH GENEVA
- 国际申请： PCT/IB2012/054305 WO 20120824
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; A61K45/06 ; C07D417/04 ; C07D409/04 ; A61K31/4725 ; A61K31/506
摘要：
In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.