A radiator structure for a two-wheeled vehicle includes a radiator main body having a front surface positioned to face a running direction, and a radiator grill having a mesh part which is positioned in front of the radiator main body to cover the radiator main body. The radiator grill is positioned behind a front wheel of the two-wheeled vehicle and has a mud guard portion which fills in the mesh part in a region SWF onto which the front wheel is projected as viewed from the front.