发明申请
- 专利标题： ANALYTICAL METHOD FOR FAB AND FAB' MOLECULES
- 专利标题（中）： FAB和FAB'分子的分析方法
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申请号： US14275055申请日： 2014-05-12
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公开(公告)号： US20140242625A1公开(公告)日： 2014-08-28
- 发明人: BRYAN JOHN SMITH , HELEN MARIE KIRKE
- 申请人： UCB PHARMA, S.A.
- 申请人地址： BE BRUSSELS
- 专利权人： UCB PHARMA, S.A.
- 当前专利权人： UCB PHARMA, S.A.
- 当前专利权人地址： BE BRUSSELS
- 优先权： GB1012784.3 20100729
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37
摘要：
A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.
公开/授权文献
- US09096887B2 Analytical method for fab and fab′ molecules 公开/授权日：2015-08-04
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