发明申请
US20140243401A1 METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND
审中-公开
筛选化合物对肿瘤细胞的细胞毒性的方法和使用这种化合物治疗肿瘤细胞的方法
- 专利标题： METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND
- 专利标题（中）： 筛选化合物对肿瘤细胞的细胞毒性的方法和使用这种化合物治疗肿瘤细胞的方法
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申请号： US13989731申请日： 2011-11-23
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公开(公告)号： US20140243401A1公开(公告)日： 2014-08-28
- 发明人: Frank Kuhajda , Gabrielle Ronnett , Craig Townsend
- 申请人： Gabrielle Ronnett
- 申请人地址： US MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore
- 国际申请： PCT/US11/62132 WO 20111123
- 主分类号： G01N33/50
- IPC分类号： G01N33/50
摘要：
The invention relates to methods of screening to find compounds that are cytotoxic to tumor cells and methods of treating tumor cells using these compounds. In particular, the invention relates to methods of screening for compounds that inhibit mammalian mitochondrial fatty acid synthase (mmFAS) and methods of treating tumor cells using mmFAS inhibitors. This invention also provides methods for inhibiting or preventing cancer cell survival by the administration of mitochondrial fatty acid synthase (FAS) inhibitors. Specifically, this invention describes a method for prohibiting or delaying the development of cancer, the growth of cancer or invasion of cancer from pre-malignant (noninvasive) lesions, or metastasis of cancer based upon the findings that this method compromises energy balance in cancer cells, in turn compromising their basic functions and causing their cell death. Compositions of matter containing mitochondrial FAS inhibition activity are also provided, as well as applications based upon the requisite role of mitochondrial FAS in cancer cell homeostasis.
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