发明申请
- 专利标题： AMORPHOUS ASIATIC TROMETHAMINE SALT AND PREPARATION METHOD THEREOF
- 专利标题（中）： 非晶亚硫胺盐及其制备方法
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申请号： US14006198申请日： 2012-03-21
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公开(公告)号： US20140243553A1公开(公告)日： 2014-08-28
- 发明人: Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
- 申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- 当前专利权人： SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- 当前专利权人地址： CN Shanghai
- 优先权： CN201110069862.6 20110322
- 国际申请： PCT/CN2012/072690 WO 20120321
- 主分类号： C07C227/14
- IPC分类号： C07C227/14 ; C07C229/38
摘要：
An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
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