Optical probe delivery and retrieval systems and methods are disclosed. The optical probe includes a dissolvable capsule that contains micro-components that are substantially smaller than the size of the capsule. The capsule is allowed to dissolve in the stomach after imaging data is collected in the esophagus. Thus, only the optical fiber tether and the relatively small micro-components attached thereto need be retrieved. Delivery devices that facilitate comfortable delivery and retrieval of the optical probe are also disclosed.