A set for and method of positioning and aligning a disruptor for the deactivation of a target and including a firing axis, a firing direction in terms of position and orientation relative to the target. The method including disposing a laser, adapted to emit beams along an aiming line, at a distance from the target such that the aiming line of the laser is coaxial with the firing direction. The disruptor is interposed between the laser and the target and positioned and oriented to make the firing axis thereof coaxial with the aiming line, by means of a flat mirror mounted at the rear of the disruptor and disposed perpendicularly to the axis of the disruptor. The mirror reflects a beam to the laser that is coaxial with the aiming line and emitted by the laser onto a mark on the mirror and centered on the firing axis.