发明申请
- 专利标题： INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS
- 专利标题（中）： 流感疫苗，包括颗粒剂和免疫调节剂的组合
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申请号： US14194525申请日： 2014-02-28
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公开(公告)号： US20140248312A1公开(公告)日： 2014-09-04
- 发明人: Rino RAPPUOLI , Derek O'HAGAN , Giuseppe DEL GIUDICE
- 申请人： NOVARTIS VACCINES AND DIAGNOSTICS SRL
- 申请人地址： IT Siena
- 专利权人： NOVARTIS VACCINES AND DIAGNOSTICS SRL
- 当前专利权人： NOVARTIS VACCINES AND DIAGNOSTICS SRL
- 当前专利权人地址： IT Siena
- 主分类号： A61K47/02
- IPC分类号： A61K47/02 ; A61K39/145
摘要：
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.
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