发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR SILENCING ALDEHYDE DEHYDROGENASE
- 专利标题（中）： 用于沉淀醛脱氢酶的组合物和方法
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申请号： US14349619申请日： 2012-10-04
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公开(公告)号： US20140248338A1公开(公告)日： 2014-09-04
- 发明人: Ian MacLachlan , Amy C.H. Lee
- 申请人： Protiva Biotherapeutics, Inc.
- 申请人地址： CA BC Burnaby
- 专利权人： Protiva Biotherapeutics, Inc.
- 当前专利权人： Protiva Biotherapeutics, Inc.
- 当前专利权人地址： CA BC Burnaby
- 国际申请： PCT/US12/58770 WO 20121004
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K9/127 ; A61K31/713
摘要：
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target aldehyde dehydrogenase (ALDH) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating alcoholism in humans).
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