发明申请
- 专利标题： Chiral compounds of varying conformational rigidity and methods of synthesis
- 专利标题（中）： 不同构象刚性和合成方法的手性化合物
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申请号： US14343426申请日： 2012-09-07
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公开(公告)号： US20140271488A1公开(公告)日： 2014-09-18
- 发明人: Glenn C. Micalizio , Thomas Kodadek , Mohosin Sarkar
- 申请人： The Scripps Research Institute
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 国际申请： PCT/US12/54135 WO 20120907
- 主分类号： C07K5/08
- IPC分类号： C07K5/08 ; C07C57/54 ; A61K45/06 ; C07C57/60 ; A61K31/192 ; A61K38/06 ; C07C51/00 ; A61K31/19
摘要：
Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases.
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