- 专利标题: THERAPEUTIC USE OF ANTIBODIES TO HGF
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申请号: US13803768申请日: 2013-03-14
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公开(公告)号: US20140271664A1公开(公告)日: 2014-09-18
- 发明人: Leon F. Garcia-Martinez , Andrew Lawrence Feldhaus , Katherine Olson , Benjamin H. Dutzar , John A. Latham
- 申请人: Leon F. Garcia-Martinez , Andrew Lawrence Feldhaus , Katherine Olson , Benjamin H. Dutzar , John A. Latham
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; A61K45/06 ; A61K39/395
摘要:
The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired.
公开/授权文献
- US09062104B2 Therapeutic use of antibodies to HGF 公开/授权日:2015-06-23