发明申请
- 专利标题： NOVEL TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
- 专利标题（中）： 新型临床阳离子脂肪及其使用方法
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申请号： US13870951申请日： 2013-04-25
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公开(公告)号： US20140288146A1公开(公告)日： 2014-09-25
- 发明人: James Heyes , Mark Wood , Alan Martin
- 申请人： PROTIVA BIOTHERAPEUTICS, INC.
- 申请人地址： CA Burnaby
- 专利权人： Protiva Biotherapeutics, Inc.
- 当前专利权人： Protiva Biotherapeutics, Inc.
- 当前专利权人地址： CA Burnaby
- 主分类号： A61K47/44
- IPC分类号： A61K47/44 ; C07C271/20 ; A61K31/7088 ; C07C229/12
摘要：
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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