Invention Application
- Patent Title: NON-NATURAL MIC PROTEINS
- Patent Title (中): 非天然麦芽糖蛋白
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Application No.: US14311130Application Date: 2014-06-20
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Publication No.: US20140302072A1Publication Date: 2014-10-09
- Inventor: David W. MARTIN, JR. , Steven R. Williams
- Applicant: David W. MARTIN, JR. , Steven R. Williams
- Applicant Address: US CA South San Francisco
- Assignee: AvidBiotics Corp.
- Current Assignee: AvidBiotics Corp.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07K14/47
- IPC: C07K14/47

Abstract:
This invention describes soluble, monovalent, non-natural protein molecules that can activate NK cells and certain T-cells to attack specific cellular target cells by attaching the NKG2D-binding portions of monovalent MICA or MICB protein, i.e. their α1-α2 platform domain, to the intended target cell specifically. The α1-α2 domain is contiguous with a heterologous α3 domain that has been genetically modified to bind directly or indirectly to the extracellular aspect of the target cell, thereby serving as the targeting domain. The genetic modification to create a non-natural and non-terminal targeting motif within the α3 domain can include a portion of an antibody, another protein molecule or portion thereof, a peptide, or a non-natural, modified α3 domain of a MIC protein.
Public/Granted literature
- US09079969B2 Non-natural MIC proteins Public/Granted day:2015-07-14
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