Embodiments of the present invention provide a base station handover method, an X2 interface setup method, a base station, a user equipment and a system. The method includes sending a handover request instruction to a second base station. The handover request instruction includes information of a first coordinated multi-point set of a user equipment. A handover request response is received from the second base station. The handover request response includes information of a second coordinated multi-point set allocated by the second base station for the user equipment. The information of the second coordinated multi-point set sent to the user equipment.