An engine having DME pilot ignition is disclosed. DME Pilot ignition creates far more energy than a conventional spark plug, thus minimizes the possibility of misfire in the engine map. DME injection can be used in a number of ways. In one embodiment, DME injection replaces the conventional spark plug in an Otto cycle engine. In another embodiment, DME injection is used in addition to spark ignition to minimize the use of DME. In this embodiment, DME injection is only used during those portions of the engine map where misfire may occur, or during those times when a misfire sensor detects misfire. DME injection can also be used in conjunction with alcohol boosting in other embodiments.