Embodiments of a blister sheet used to manage prescription pills are described herein and include a plurality of spaced-apart cavities, each surrounded by a flange on an open side of each cavity. The flanges together defining a top surface of the blister sheet. Two adjacent cavities are attached by adjacent sides of their respective flanges. Each of the adjacent sides having two longitudinal ends, each having a notch. When a sealing sheet is secured onto the top surface, the notches define unattached portions of the sealing sheet that can be used to grip onto the sealing sheet for its detachment from the top surface. The flanges of two adjacent individual blisters are joined by a tearing line that is weaker at the longitudinal ends thereof.