Techniques for mitigating interference due to peer-to-peer (P2P) communication are described. In an aspect, a P2P UE may measure the signal strength of downlink signals from base stations and may set its transmit power based on (e.g., proportional to) the measured signal strength in order to mitigate interference to WWAN UEs communicating with base stations. In another aspect, the P2P UE may measure the signal strength of uplink signals from WWAN UEs and may set its transmit power based on (e.g., inversely proportional to) the measured signal strength in order to mitigate interference to the WWAN UEs. In one design, the P2P UE may measure the signal strength of an uplink signal from a WWAN UE, estimate the pathloss between the two UEs based on the measured signal strength, and determine its transmit power based on the estimated pathloss.