Invention Application
US20140328809A1 METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS
审中-公开
使用合成三聚磷酸酯诱导骨髓干细胞成纤维细胞生成的方法
- Patent Title: METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS
- Patent Title (中): 使用合成三聚磷酸酯诱导骨髓干细胞成纤维细胞生成的方法
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Application No.: US14358077Application Date: 2012-11-14
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Publication No.: US20140328809A1Publication Date: 2014-11-06
- Inventor: Gordon W. Gribble , Damian Medici , Pamela Gehron Robey , Karen T. Liby , Michael B. Sporn , Nanjoo Suh
- Applicant: TRUSTEES OF DARTMOUTH COLLEGE , THE UNITED STATES OF AMERICA, as represented byTHE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE , RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- International Application: PCT/US2012/064909 WO 20121114
- Main IPC: A61K35/32
- IPC: A61K35/32 ; A61K31/277 ; C12N5/077 ; A61K31/4164
Abstract:
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.
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