发明申请
US20140336195A1 ARYLOXMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS
有权
作为PDE10抑制剂的ARYLOXMETHYL CYCLOPROPANE DORIVATIVES
- 专利标题： ARYLOXMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS
- 专利标题（中）： 作为PDE10抑制剂的ARYLOXMETHYL CYCLOPROPANE DORIVATIVES
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申请号： US14117313申请日： 2012-05-21
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公开(公告)号： US20140336195A1公开(公告)日： 2014-11-13
- 发明人: Michael J. Breslin , Christopher D. Cox , Timothy J. Hartingh , Joseph Pero , Izzat T. Raheem , Michael Rossi , Laura Vassallo
- 申请人： Michael J. Breslin , Christopher D. Cox , Timothy J. Hartingh , Joseph Pero , Izzat T. Raheem , Michael Rossi , Laura Vassallo
- 国际申请： PCT/US12/38759 WO 20120521
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D413/14 ; C07D417/14 ; C07D401/12 ; C07D471/04 ; C07D401/14
摘要：
The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
公开/授权文献
- US08975261B2 Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors 公开/授权日：2015-03-10
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