Invention Application
- Patent Title: IP receptor agonist heterocyclic compounds
- Patent Title (中): IP受体激动剂杂环化合物
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Application No.: US14371575Application Date: 2013-01-11
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Publication No.: US20140357641A1Publication Date: 2014-12-04
- Inventor: Gurdip Bhalay , Steven Carl Chatlton , Mark Patrick Healy , Catherine Leblanc , Stephen Carl McKeown
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- International Application: PCT/IB2013/050277 WO 20130111
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/4985
Abstract:
The present invention provides heterocyclic derivatives which activate the IP receptor, processes for preparing them, pharmaceutical compositions comprising said derivatives and uses thereof. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Formula (I):
Information query
