发明申请
- 专利标题： METHODS FOR SUPPRESSING CANCER BY INHIBITION OF TMCC3
- 专利标题（中）： 抑制TMCC3抑制癌症的方法
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申请号： US14223800申请日： 2014-03-24
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公开(公告)号： US20140363372A1公开(公告)日： 2014-12-11
- 发明人: Alice L. Yu , John Yu , Ya-Hui Wang , Chuan-Lung Hsu , Yi-Chang Chen , Ying-Yung Lok
- 申请人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY , CHANG GUNG MEMORIAL HOSPITAL , ACADEMIA SINICA
- 申请人地址： TW New Taipei City TW Taoyuan County TW Taipei City
- 专利权人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY,CHANG GUNG MEMORIAL HOSPITAL,ACADEMIA SINICA
- 当前专利权人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY,CHANG GUNG MEMORIAL HOSPITAL,ACADEMIA SINICA
- 当前专利权人地址： TW New Taipei City TW Taoyuan County TW Taipei City
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; G01N33/574 ; C12Q1/68 ; A61K51/10
摘要：
A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.
公开/授权文献
- US09447193B2 Methods for suppressing cancer by inhibition of TMCC3 公开/授权日：2016-09-20