发明申请
- 专利标题: Hydrazide Containing Nuclear Transport Modulators And Uses Thereof
- 专利标题(中): 含有核运输调节剂的酰肼及其用途
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申请号: US14235306申请日: 2012-07-29
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公开(公告)号: US20140364408A1公开(公告)日: 2014-12-11
- 发明人: Vincent P. Sandanayaka , Sharon Shacham , Dilara McCauley , Sharon Shechter
- 申请人: Vincent P. Sandanayaka , Sharon Shacham , Dilara McCauley , Sharon Shechter
- 申请人地址: US MA Natick
- 专利权人: KARYOPHARM THERAPEUTICS INC.
- 当前专利权人: KARYOPHARM THERAPEUTICS INC.
- 当前专利权人地址: US MA Natick
- 国际申请: PCT/US2012/048319 WO 20120729
- 主分类号: C07D249/08
- IPC分类号: C07D249/08 ; C07D403/12 ; A61K31/4439 ; A61K31/55 ; A61K31/454 ; A61K31/4196 ; A61K31/506 ; A61K31/498 ; A61K31/497 ; C07D401/12
摘要:
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.