发明申请
US20140364443A1 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
有权
1,4-二氢萘啶衍生物和药物组合物及其用途
- 专利标题： 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
- 专利标题（中）： 1,4-二氢萘啶衍生物和药物组合物及其用途
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申请号： US14362735申请日： 2012-12-07
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公开(公告)号： US20140364443A1公开(公告)日： 2014-12-11
- 发明人: Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
- 申请人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
- 申请人地址： CN Jiangsu
- 专利权人： Jiangsu Simovay Pharmaceutical Co., Ltd.
- 当前专利权人： Jiangsu Simovay Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Jiangsu
- 优先权： CN201110405079.2 20111207
- 国际申请： PCT/CN2012/086145 WO 20121207
- 主分类号： C07D495/14
- IPC分类号： C07D495/14 ; C07D471/14 ; C07D471/04
摘要：
Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.