发明申请
- 专利标题： INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER
- 专利标题（中）： 用于治疗耐药前列腺癌的吲哚美辛类似物
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申请号： US14352421申请日： 2012-10-17
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公开(公告)号： US20140371261A1公开(公告)日： 2014-12-18
- 发明人: Lawrence J. Marnett , Andy J. Liedtke , Trevor M. Penning , Adegoke O. Adeniji , Michael C. Byrns
- 申请人： Vanderbilt University , The Trustees of the University of Pennsylvania
- 申请人地址： US PA Philadelphia US Nashville
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,VANDERBILT UNIVERSITY
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,VANDERBILT UNIVERSITY
- 当前专利权人地址： US PA Philadelphia US Nashville
- 国际申请： PCT/US2012/060508 WO 20121017
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D209/70 ; C07D231/56 ; C07D209/08
摘要：
Provided are compositions for inhibiting a biological activity of an aldoketo reductase family 1, member C3 (AKR1 C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1 C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
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